Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham

Table 2

Anti-HIV-1 integrase activity of pure compounds from B. alnoides.

Sample	% Inhibition at various concentrations (μM)	IC50 (μM)
		1	3	10	30	100
Betulinic acid (1)	—	—	39.0 ± 2.3	53.2 ± 1.2	65.6 ± 2.1	24.8 ± 1.3^c
Betulin (2)	—	—	41.2 ± 1.5	57.6 ± 1.2	70.7 ± 2.1	17.7 ± 0.6^b
Lupeol (3)	—	—	12.2 ± 1.3	25.9 ± 2.0	40.6 ± 1.8	>100
Oleanolic acid (4)	—	—	33.4 ± 1.8	49.1 ± 2.2	65.5 ± 1.5	30.3 ± 1.3^d
Ursolic acid (5)	—	—	31.6 ± 0.9	48.5 ± 1.2	60.2 ± 2.1	35.0 ± 1.0^e
Suramin	32.1 ± 0.6	50.3 ± 1.6	70.9 ± 1.5	93.3 ± 1.3	99.9 ± 1.7	2.8 ± 0.1^a

Each value represents the mean ± S.E.M. of four determinations. Different characters (a, b, c, d, and e) indicate significant differences among the compared means in the same treatment group at .