Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice

<div>Effects of oleander extracts on body weight (BW) and glucose metabolism. Alloxanized T1D mice (glucose &gt;200 mg/dL) were treated with 200 mg/kg oleander stem (NOSE) and root (NORE) extracts for 20 consecutive days, and glibenclamide (Glib) was used as standard. After the intervention, (a) BW increase of NOSE- and NORE-treated mice were lower compared to day 0, which was otherwise significantly higher in T1D group at day 20. (b) In agreement to the hypothesized antidiabetic activity, blood glucose level was decreased in the alloxanized mice due to NOSE and NORE treatment. 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Advances in Pharmacological and Pharmaceutical Sciences

fig1

Figure 1

Figure 1: Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice 