Research Article
Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice
Table 1
Effect of NOSE and NORE on serum enzymatic and biochemical parameters.
| | Control | Alloxan | T1D | Glibenclamide | NOSE | NORE |
| ACP | 3.39 ± 0.09 | 8.06 ± 0.76 | 5.79 ± 0.25δ | 6.15 ± 0.38γ | 5.06 ± 0.24γ | ALP | 10.90 ± 1.07 | 21.85 ± 1.52 | 11.61 ± 1.25NSα | 14.0 ± 0.37γ | 12.44 ± 0.36NSβ | ALT | 43.12 ± 1.57 | 89.13 ± 7.05 | 54.72 ± 2.30γ | 65.27 ± 2.38γ | 54.88 ± 5.97NSγ | AST | 68.32 ± 8.08 | 95.87 ± 4.86NS | 74.90 ± 1.91NSγ | 85.72 ± 3.89NSβ | 73.95 ± 2.24NSγ | Cholesterol | 78.31 ± 6.49 | 121.29 ± 3.04 | 75.67 ± 3.07NSβ | 104.92 ± 2.49NSγ | 85.50 ± 4.44NSα | Triglyceride | 92.1 ± 4.15 | 139.19 ± 5.77 | 95.91 ± 4.24NSβ | 121.95 ± 5.96γ | 109.97 ± 4.25γ | Creatinine | 0.18 ± 0.01 | 0.33 ± 0.01 | 0.19 ± 0.01NSγ | 0.27 ± 0.00γ | 0.25 ± 0.01β | BUN | 8.55 ± 1.08 | 24.90 ± 3.00 | 12.19 ± 3.08NSδ | 17.20 ± 0.50γ | 14.08 ± 1.02γ | Uric acid | 1.77 ± 0.15 | 2.50 ± 0.20NS | 1.90 ± 0.12NSα | 2.09 ± 0.03NSδ | 1.86 ± 0.09NSγ |
|
|
NS = nonsignificant ( ), , , and vs control. α, β, γ, and δ compared to T1D. ACP: acid phosphatase; ALP: alanine aminotransferase; ALT: alanine transaminase; AST: aspartate transaminase; BUN: blood urea nitrogen; NOSE: Nerium oleander stem extract; NORE: Nerium oleander root extract; T1D: type 1 diabetes. |