Novel Dimethylacetamide-Containing Formulation Improves Infraorbital Anaesthesia Efficacy in Rats with Periodontitis

Table 1

Local oxidative stress activity and tissue IL-1β, IL-10, and TNF-α concentration in the gingival mucosa of rats with periodontitis one day after LHT-15-32 infraorbital application.

Group of animals	Chemiluminescence, × 10^3 imp/s		Cytokine level, pcg/g
	OSA	TAC	IL-1β	IL-10	TNF-α
Intact group, n = 10	2.8 ± 0.2	3.1 ± 0.3	0.3 ± 0.1	15.8 ± 0.5	12.4 ± 1.8
Control, n = 10	8.3 ± 0.4	1.0 ± 0.2	3.2 ± 0.4	3.6 ± 0.3	129.3 ± 4.9
2% lidocaine, n = 10	6.4 ± 0.7	1.7 ± 0.4	3.0 ± 0.2	4.7 ± 0.4	110.6 ± 3.5
2% LHT-4-00, n = 10	5.4 ± 0.4	3.9 ± 0.3^†#	2.7 ± 0.3	3.9 ± 0.3	103.9 ± 4.1
2% LHT-15-32, n = 10	3.2 ± 0.3^†#	4.7 ± 0.5^†#	0.9 ± 0.1	4.3 ± 0.5	23.7 ± 2.3^†#

Note: ; when compared with the intact group; ^#when compared with the control; ^†when compared with the lidocaine group (ANOVA; Newman–Keuls criterion).