Research Article
Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets
Table 10
Constrains of factors and responses for optimization of the FDC of MET HCl and GLB ODTs.
| | Name | Goal | Lower limit | Upper limit | Lower weight | Upper weight | Importance |
| | PEG 6000 (%) | Range | 2 | 7 | 1 | 1 | 3 | | Crospovidone (%) | Range | 2 | 10 | 1 | 1 | 3 | | Compression force (kN) | Range | 5 | 15 | 1 | 1 | 3 | | Friability (%) | Range | 0.15 | 0.5 | 1 | 1 | 3 | | Disintegration time (sec) | Range | 11 | 30 | 1 | 1 | 3 |
|
|
