Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Table 12

Granule and tablet properties of the optimized FDC of MET HCl and GLB formulation.

Parameters					Experimental value
Granule properties
Bulk density (gm/mL)					0.53 + 0.02
Tapped density (gm/mL)					0.61 + 0.00
Hausner’s ratio					1.15 + 0.00
Carr’s index (%)					13.11 + 0.90
Angle of repose (°)					26.00 + 0.80
Tablet properties
Formulation code	Diameter (mm)	Thickness (mm)	Hardness (kg/cm^2)	Weight (mg)	Assay (%)
					MET	GLB
F1	10.02 ± 0.00	3.83 ± 0.04	7.83 + 0.12	349.30 ± 1.6	98.08 + 0.92	104.34 + 0.21
F2	10.04 ± 0.02	3.84 ± 0.02	7.82 + 0.68	348.90 ± 2.0	101.05 + 0.61	101.59 + 0.13
F3	9.92 ± 0.14	3.83 ± 0.04	7.84 + 0.05	348.70 ± 2.4	96.79 + 0.32	100.68 + 0.74