Research Article
Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets
Table 12
Granule and tablet properties of the optimized FDC of MET HCl and GLB formulation.
| Parameters | | | | | Experimental value |
| Granule properties | Bulk density (gm/mL) | | | | | 0.53 + 0.02 | | Tapped density (gm/mL) | | | | | 0.61 + 0.00 | | Hausner’s ratio | | | | | 1.15 + 0.00 | | Carr’s index (%) | | | | | 13.11 + 0.90 | | Angle of repose (°) | | | | | 26.00 + 0.80 | | Tablet properties | Formulation code | Diameter (mm) | Thickness (mm) | Hardness (kg/cm2) | Weight (mg) | Assay (%) | MET | GLB | F1 | 10.02 ± 0.00 | 3.83 ± 0.04 | 7.83 + 0.12 | 349.30 ± 1.6 | 98.08 + 0.92 | 104.34 + 0.21 | F2 | 10.04 ± 0.02 | 3.84 ± 0.02 | 7.82 + 0.68 | 348.90 ± 2.0 | 101.05 + 0.61 | 101.59 + 0.13 | F3 | 9.92 ± 0.14 | 3.83 ± 0.04 | 7.84 + 0.05 | 348.70 ± 2.4 | 96.79 + 0.32 | 100.68 + 0.74 |
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