Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Table 4

Experimental levels of the independent variables for optimizing the fixed-dose combination of metformin HCl and glibenclamide orodispersible tablets.

Variables	Levels
	−α	−1	0	+1	+α
PEG 6000 (%)	0.296	2	4.5	7	8.70
Crospovidone (%)	−0.727	2	6	10	12.7
Compression force (kN)	1.59	5	10	15	18.40

α = 1.68179.