Research Article
Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets
Table 7
Composition of 19 formulations based on the central composite design.
| Formulation code | Point type | Independent variables | PEG 6000 (%) | Crospovidone (%) | Compression force (kN) |
| Fd1 | Axial | 4.5(0) | 6(0) | 18.41(+α) | Fd2 | Center | 4.5(0) | 6(0) | 10(0) | Fd3 | Factorial | 2(−1) | 2(−1) | 5(−1) | Fd4 | Center | 4.5(0) | 6(0) | 10(0) | Fd5 | Factorial | 7(+1) | 2(−1) | 5(−1) | Fd6 | Factorial | 2(−1) | 10(+1) | 15(+1) | Fd7 | Axial | 4.5(0) | 6(0) | 1.59 α | Fd8 | Factorial | 2(−1) | 2(−1) | 15(+1) | Fd9 | Factorial | 2(−1) | 10(+1) | 5(−1) | Fd10 | Factorial | 7(+1) | 2(−1) | 15(+1) | Fd11 | Axial | 4.5(0) | 12.7(+α) | 10(0) | Fd12 | Center | 4.5(0) | 6(0) | 10(0) | Fd13 | Factorial | 7(+1) | 10(+1) | 15(+1) | Fd14 | Axial | 8.7 (+α) | 6(0) | 10(0) | Fd15 | Axial | 4.7(0) | 2(−α) | 10(0) | Fd16 | Axial | 0.296(−α) | 6(0) | 10(0) | Fd17 | Center | 4.5(0) | 6(0) | 10(0) | Fd18 | Center | 4.5(0) | 6(0) | 10(0) | Fd19 | Factorial | 7(+1) | 10(+1) | 5(−1) |
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Fd = formulation design based on the CCD.
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