Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats

Table 3

Effect of APN on weight gained, lee index, BMI, fasting plasma glucose and insulin level, and insulin resistance.

	Control diet	HFHF diet	HFHF + 100 mg/kg BW APN	HFHF + 200 mg/kgBW APN	HFHF + 400 mg/kgBW APN
Food intake (g)	18.50 ± 0.57	14.93 ± 0.69^#	12.30 ± 0.69^#	12.33 ± 1.04^#	13.25 ± 1.11^#
Water/high fructose (ml)	31.98 ± 0.66	22.97 ± 1.10^#	20.62 ± 1.21^#	21.03 ± 1.11^#	22.33 ± 1.31^#
Weight gained at 9 weeks (g)	57.50 ± 7.52	70.33 ± 5.36	39.17 ± 2.50	42.80 ± 3.95	51.00 ± 9.01
BMI (g/cm^2)	0.55 ± 0.02	0.65 ± 0.02^#	0.57 ± 0.02	0.52 ± 0.01	0.54 ± 0.02
Lee index	0.294 ± 0.006	0.313 ± 0.005	0.314 ± 0.013	0.294 ± 0.05	0.299 ± 0.007
Plasma glucose (mmol/l)	7.57 ± 1.05	11.15 ± 0.58^#	6.80 ± 0.63	7.16 ± 0.48	6.37 ± 1.07
Insulin level (mlU/L)	7.78 ± 1.21	10.53 ± 0.61^#	7.37 ± 1.16	9.62 ± 0.21	9.59 ± 0.51
HOMA-IR	2.77 ± 0.64	5.40 ± 0.56^#	2.13 ± 0.29	3.09 ± 0.20	2.66 ± 0.38

Values are represented as mean ± SEM. Values on the same row with # are significantly () different from control while those with are significantly different () from the HFHF-fed group.