Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats
Table 4
Effect of APN on the liver and kidney function.
Control diet
HFHF diet
HFHF + 100 mg/kg BW APN
HFHF + 200 mg/kgBW APN
HFHF + 400 mg/kgBW APN
Liver weight (g)
7.25 ± 0.28
8.23 ± 0.53
7.08 ± 0.71
6.27 ± 0.14
6.75 ± 0.43
Kidney weight (g)
2.57 ± 0.31
2.76 ± 0.17
2.90 ± 0.31
2.90 ± 0.23
2.40 ± 0.18
Total protein (mg/ml)
55.67 ± 0.76
73.31 ± 2.52
68.80 ± 3.63
64.64 ± 5.76
83.65 ± 6.23
ALP (U/l)
117.76 ± 10.78
150.88 ± 22.17
111.09 ± 8.80
74.70 ± 8.69
84.64 ± 6.46
AST (U/l)
25.04 ± 0.48
34.32 ± 1.33
24.46 ± 3.11
30.76 ± 4.60
29.39 ± 5.38
ALT (U/l)
41.43 ± 2.95
62.94 ± 4.26
26.80 ± 5.57
17.81 ± 1.75
18.82 ± 0.85
Albumin (U/l)
4.63 ± 0.16
4.01 ± 0.16
5.09 ± 0.54
4.64 ± 0.47
3.82 ± 0.58
Plasma urea (mg/dl)
61.87 ± 1.75
62.69 ± 4.24
70.69 ± 5.14
65.33 ± 2.64
69.39 ± 3.51
Kidney urea (mg/dl
32.87 ± 4.21
42.29 ± 4.85
50.04 ± 6.54
52.70 ± 6.37
49.69 ± 2.64
Plasma creatinine (mg/dl)
3.64 ± 0.19
3.63 ± 0.51
3.33 ± 0.23
3.41 ± 0.21
3.17 ± 0.07
Kidney creatinine (mg/dl)
2.45 ± 0.21
2.31 ± 0.30
2.18 ± 0.13
1.97 ± 0.14
2.80 ± 0.85
Values are represented as mean ± SEM. Values on the same row with are significantly () different from control while those with are significantly different () from HFHF-fed group.
