Hydroethanolic Stem Bark Extract of <i>Burkea africana</i> Attenuates Vincristine-Induced Peripheral Neuropathy in Rats

<div>Effect of BAE (50–1000 mg kg<sup>−1</sup> <i>p.o</i>.) and PGABA (10–100 mg kg<sup>−1</sup> <i>p.o.</i>) on vincristine-induced cold allodynia in rats. Upper panel shows the time-course effect whiles the lower panel represents the bar graphs of the AUCs respectively. <span class="nowrap"><svg height="10.7395pt" id="M58" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 80.1879 10.7395" width="80.1879pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 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hoc test). <span class="nowrap"><svg height="11.4337pt" id="M60" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.7967 80.1879 11.4337" width="80.1879pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M556 236V289H337V504H275V289H56V236H275V-4H337V236H556Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,5.56,-5.741)"><path d="M556 236V289H337V504H275V289H56V236H275V-4H337V236H556Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,11.12,-5.741)"><path d="M556 236V289H337V504H275V289H56V236H275V-4H337V236H556Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,16.68,-5.741)"><path d="M556 236V289H337V504H275V289H56V236H275V-4H337V236H556Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.822,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 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Each data presented are mean ± S.E.M (<i>n</i> = 10).</div>

Advances in Pharmacological and Pharmaceutical Sciences

fig4

Figure 4

Figure 4: Hydroethanolic Stem Bark Extract of <i>Burkea africana</i> Attenuates Vincristine-Induced Peripheral Neuropathy in Rats 

Advances in Pharmacological and Pharmaceutical Sciences

Hydroethanolic Stem Bark Extract of Burkea africana Attenuates Vincristine-Induced Peripheral Neuropathy in Rats

Figure 4