Hydroethanolic Stem Bark Extract of Burkea africana Attenuates Vincristine-Induced Peripheral Neuropathy in Rats
Table 2
Effects BAE and pregabalin on biochemistry parameters of the sciatic nerve and tissue homogenate.
Group
Naïve
Vincristine control
BAE (mg kg−1)
Pregabalin (mg kg−1)
50
500
1000
10
30
100
TPC
2.57 ± 0.27
4.37 ± 0.20
3.12 ± 0.24
3.13 ± 0.18
3.06 ± 0.49
3.41 ± 0.53
2.97 ± 0.35
2.83 ± 0.18
SOD
0.71 ± 0.01
0.07 ± 0.03
0.17 ± 0.05
0.33 ± 0.01
0.43 ± 0.01
0.17 ± 0.01
0.37 ± 0.02
0.42 ± 0.00
CAT
7.48 ± 0.29
0.77 ± 0.18
3.62 ± 0.33
4.10 ± 15
4.58 ± 0.21
3.04 ± 0.11
4.06 ± 2.0
4.91 ± 0.10
GSH
686.7 ± 89.93
231.3 ± 16.36
358.1 ± 55.02
507.40 ± 31.97
548.5 ± 19.04
332.80 ± 18.70
492.10 ± 30.78
543.40 ± 44.14
MDA
30.21 ± 6.08
335.60 ± 46.35
228.50 ± 23.77
163.10 ± 10.96
98.06 ± 36.95
177.20 ± 47.45
144.0 ± 24.64
99.20 ± 34.36
MPO
62.48 ± 10.02
230.50 ± 16.27
195.80 ± 6.78
133.30 ± 4.99
106.70 ± 9.02
142.90 ± 10.10
120.90 ± 5.17
107.80 ± 7.20
Biochemical parameters were estimated from the sciatic nerve and accompanying tissue homogenate. ;;; compared with the control group (ordinary 1-way ANOVA complemented with Dunnett’s post hoc test). Each data presented are mean ± S.E.M (n = 5). TPC = total protein content, SOD = super oxide dismutase, CAT = catalase, GSH = reduced glutathione, MDA = malondialdehyde, and MPO = myeloperoxide.
