Current Status of Alginate in Drug Delivery

Table 4

Route of administration of drug delivery.

Drugs	Polymer	Route	Formulation/design approach	References
Quercetin	Na alginate and chitosan	Oral	Ionic crosslinking method for oral controlled release	[105]
Isoniazid and rifampicin	Sodium alginate	Oral	Drop technique for oral sustained delivery carriers	[106, 107]
4-(2-Aminoethyl) benzoic acid	Sodium alginate	Oral	Chemically modified (amidation and reductive amination)	[108]
Ciprofloxacin	Alginate-gelatin	Oral	Crosslinked method	[109, 110]
Bovine insulin	Sodium alginate	Oral	Ionotropic gelation using calcium chloride dihydrate	[111]
Lentivectors	Alginate	Oral	Polymers were ionically crosslinked to create bimodal hydrogel	[112]
Resveratrol	Alginate	Oral	Ionic and shelled with soy protein isolate (SPI)	[5]
Metformin	Alginate	Oral	DDS for oral antidiabetic	[113]
Metronidazole	Alginate	Oral	Matrix for oral DDS	[114]
Recombinant hepatitis B surface antigen (rHBsAg)	Alginate	Parenteral	Antigen delivery system for intramuscular administration by mild ionic crosslinking technique	[8]
Furosemide	Alginate-chitosan	Parenteral	Mucopenetrating nanoparticles for enhancement of oral bioavailability	[115]
Exemestane	Sodium alginate	Parenteral	Simple controlled gelation method for oral chemotherapeutic drug	[116]
Paclitaxel	Alginate	Pulmonary	Emulsification technique	[117]
Isoniazid rifampicin, pyrazinamide, and paclitaxel	Chitosan, alginate, PLGA, and polysaccharides	Pulmonary	Emulsification and complexation	[118]
Amikacin, ciprofloxacin, and polymyxin	PLGA and alginate	Pulmonary	Spray drying	[119]
Cisplatin and doxorubicin	Alginate, HAS, chitosan, and PLGA	Pulmonary	Emulsification/gelation and spray drying	[120]
Ciprofloxacin	Polyethylene glycol, phthaloyl chitosan, and sodium alginate	Pulmonary	Grafted and spray drying	[121]
BCG vaccine	Alginate	Pulmonary	Emulsification	[122]
Tobramycin	Alginate and chitosan	Pulmonary	Precipitation	[123]
BCG vaccine	Alginate	Pulmonary	Aerosol liquid encapsulation	[124]
BSA	Alginate	Pulmonary	Spray drying	[99]
BSA	Alginate, chitosan, and trimethyl chitosan	Pulmonary	Liposomal formulation	[125]
Ciprofloxacin	Calcium alginate	Transdermal	Lyophilized hydrogels for wound dressing	[126]
Resveratrol	Chitosan, alginate, and poly(d,l-lactide-co-glycolide)	Transdermal	Nanoprecipitation	[127]
Metronidazole	Alginate	Transdermal	Ionotropic gelation combination with freeze-thawing cycle	[128, 129]