Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice

Table 1

Effects of the aqueous (AE) and ethanol (EE) extracts of Dissotis thollonii on blood glucose after injection of streptozotocin in mice.

Treatment	Dose (mg/kg)	Period (weeks)
		0	1	2	3	4	5	6
Normal control	—	106.67 ± 3.24	104.27 ± 2.18	109.07 ± 5.05	107.67 ± 3.62	104.67 ± 3.93	105.57 ± 2.99	106.40 ± 4.01
Diabetic control	—	104.06 ± 2.82	380.20 ± 8.50^λ	440.03 ± 18.27^λ	446.50 ± 17.88^λ	445.03 ± 20.59^λ	448.23 ± 18.13^λ	456.50 ± 14.27^λ
Pregabalin	30	109.67 ± 4.91	381.00 ± 8.65^λ	434.50 ± 24.89^λ	358.33 ± 13.04^λc	354.33 ± 9.28^λc	357.83 ± 13.19^λc	352.13 ± 11.73^λc
Aqueous extract	250	108.33 ± 0.95	369.33 ± 13.53^λ	438.59 ± 10.54^λ	435.00 ± 4.20^λ	432.62 ± 10.98^λ	428.14 ± 16.35^λ	431.83 ± 14.33^λ
	500	105.50 ± 1.12	361.67 ± 12.33^λ	407.83 ± 13.19^λ	405.50 ± 9.28^λ	404.23 ± 10.47^λ	407.83 ± 12.74^λ	401.83 ± 6.21^λ
Ethanol extract	250	107.00 ± 1.34	376.21 ± 16.17^λ	421.03 ± 12.92^λ	438.33 ± 14.77^λ	429.30 ± 12.72^λ	430.50 ± 16.83^λ	425.17 ± 17.32^λ
	500	106,83 ± 1.47	355.05 ± 9.17^λ	387.19 ± 6.01^λ	388.83 ± 24.59^λ	387.07 ± 19.08^λ	386.17 ± 16.26^λ	378.50 ± 17.67^λ

Values are expressed as mean ± SEM for six animals and analyzed by one-way ANOVA followed by the Tukey post hoc test. ^λ when compared with the normal control and ^c when compared with the diabetic control.