Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice

Table 2

Effects of the aqueous (AE) and ethanol (EE) extracts of Dissotis thollonii on body weight after injection of streptozotocin in mice.

Treatment	Dose (mg/kg)	Period (weeks)
		0	1	2	3	4	5	6
Normal control	—	23.00 ± 0.88	25.00 ± 1.57	27.33 ± 0.80	29.00 ± 0.82	29.50 ± 1.50	31.00 ± 0.93	31.77 ± 0.99
Diabetic control	—	25.11 ± 1.78	23.22 ± 1.41	21.78 ± 0.24^α	21.01 ± 0.67^λ	19.37 ± 0.44^λ	18.00 ± 0.64^λ	17.33 ± 0.23^λ
Pregabalin	30	26.67 ± 1.52	24.50 ± 0.81	22.17 ± 0.60^α	21.17 ± 0.89^λ	20.67 ± 0.92^λ	19.17 ± 0.79^λ	18.00 ± 0.52^λ
Aqueous extract	250	24.50 ± 1.92	22.17 ± 1.28	21.50 ± 1.29^β	20.50 ± 1.15^λ	19.41 ± 1.43^λ	18.83 ± 1.20^λ	17.09 ± 0.73^λ
	500	25.30 ± 1.69	21.53 ± 0.32	19.83 ± 0.62^λ	18.83 ± 0.60^λ	18.69 ± 0.83^λ	18.00 ± 0.76^λ	16.83 ± 0.70^λ
Ethanol extract	250	25.12 ± 2.03	23.11 ± 0.68	20.83 ± 0.68^λ	19.17 ± 0.73^λ	18.83 ± 0.86^λ	17.83 ± 0.72^λ	16.33 ± 0.56^λ
	500	26.33 ± 1.37	23.28 ± 0.31	21.75 ± 0.47^λ	19.67 ± 0.61^λ	18.17 ± 0.29^λ	17.35 ± 0.40^λ	16.22 ± 0.83^λ

Values are expressed as mean ± SEM for six animals and analyzed by one-way ANOVA followed by the Tukey post hoc test. ^α, ^β, ^γ when compared with the normal control.