A Pharmacokinetic Evaluation of a Pectin-Based Oral Multiparticulate Matrix Carrier of Carbamazepine

Table 3

Pharmacokinetic parameters of carbamazepine in the 4 treatment groups.

Parameter	Treatment group (mean (standard deviation))				value
	Formulation A	Formulation B	Carbamazepine powder	Tegretol CR^®
(h)	12 (1.28)	12 (1.43)	2 (0.56)	8 (2.23)	0.007
(µg/mL)	8.45 (0.71)	7.74 (0.70)	1.45 (0.45)	8.24 (0.45)	0.001
AUC0⟶36 (/mL)	176.20 (7.97)	161 (4.24)	22.05 (1.64)	155 (7.15)	<0.0001
(h^−1)	0.05 (0.01)	0.04 (0.01)	0.08 (0.03)	0.05 (0.02)	0.242
(h)	13.75 (3.28)	13.23 (1.90)	8.44 (6.97)	13.51 (2.87)	0.691

Formulation A = 100 mg carbamazepine, 200 mg CPH pectin, 50 mg calcium chloride, and 50 mg HPMC; formulation B = 100 mg carbamazepine, 200 mg CPH pectin, 50 mg calcium chloride, and 50 mg HPMC.