Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis

Table 1

Antimycobacterial activity and cytotoxicity data.

Compound	MIC99	IC50 CHO
	7H9-ADC		GAST-Fe
1 [23]	>125	>125	>10^#
2 [24]	>125	>125	>322
3 [19]	82.20	82.8	119.00
4 [23]	>125	>125	>254
5 [23]	125	80.9	84.80
6 [23]	125	>125	>254
7 [18]	68.70	>125	9.54
8 [25]	>125	>125	Nd
9 [26]	>125	>125	>414
10 [26]	>125	>125	>349
11 [27]	50.00	42.8	7.40
12 [26]	>125	>125	>386
13 [28]	>125	>125	>100^+
14 [25]	9.60	18.8	8.01
15 [25]	13.90	15.2	8.20
16	>125	>125	>100^+
Rifampicin	0.0149	0.0274	Nd
Emetine	Nd	nd	0.061

TB : MIC₉₉ 7H9 (μM) in M. tuberculosis H37Rv:gfp. TB : MIC₉₉ GAST-Fe (μM) in M. tuberculosis H37Rv:gfp. CHO : Chinese hamster ovarian cell IC₅₀ (μM) as indication of cytotoxicity [18, 19]. nd: not determined. ^#highest concentration measured.  ⁺CellTiter-Glo® luminescent cell viability assay [28].