In Vitro Comparative Quality Assessment of Different Brands of Doxycycline Hyclate Finished Dosage Forms: Capsule and Tablet in Jimma Town, South-West Ethiopia

Table 2

Pharmacopoeial quality test results for doxycycline hyclate 100 mg brands.

Sample code	Assay (±SD), n = 20	Compliance with USP assay test	Average weight (gm), n = 10 for caps and 20 for tabs (±SD)	Compliance with Int. Ph for caps, USP for tabs weight variation test	Friability (%), n = 10	Compliance with USP friability test	Average hardness in Newton	Compliance with USP hardness test
D01	97.70 (0.06)	Passed	362.68 (2.68)	Passed
D02	116.0 (0.16)	Passed	330.86 (3.98)	Passed
D03	99.40 (0.13)	Passed	283.91 (3.63)	Passed
D04	94.70 (0.13)	Passed	221.08 (3.36)	Passed
D05	93.40 (0.23)	Passed	127.22 (1.74)	Passed
D06	94.60 (0.05)	Passed	222.54 (7.03)	Passed
D07	99.30 (0.09)	Passed	140.32 (9.25)	Passed
D08	119.6 (0.07)	Passed	259.07 (1.85)	Passed	0.17	Passed	54.00 (4.06)	Passed
D09	102.0 (0.21)	Passed	264.97 (1.68)	Passed	13.78	Failed	31.83 (2.07)	Failed
D10	92.60 (1.82)	Passed	211.98 (2.13)	Passed	0.01	Passed	83.64 (6.49)	Passed

Caps: capsules; tabs: tablets; USP: United State Pharmacopeia; Int. Ph: International Pharmacopeia.