Evaluation of Anticonvulsant Activity of 80% Methanolic Root Bark Extract and Solvent Fractions of Pentas schimperiana (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice

Table 1

Anticonvulsant effect of solvent fraction of Pentas schimperiana (A. Rich.) Vatke root bark in PTZ-induced seizure.

Group	% protection from clonic seizure	% protection from mortality	Mean latency to clonic seizure (S)
NC	—	—	246.17 ± 45.13
SV200	100	100	1200.00 ± 0.00^a3c2
AF100	—	—	700.00 ± 73.76^a1b2
AF200	—	—	850.00 ± 93.49^a3
AF400	—	16.67	870.00 ± 96.44^a3
NC	—	—	246.17 ± 45.13
SV200	100	100	1200.00 ± 0.00^a3
BF100	—	16.67	1000.00 ± 100.00^a3
BF200	33.33	33.33	820.00 ± 124.58^a3
BF400	50.00	50.00	1010.00 ± 98.49^a3
NC	—	—	246.17 ± 45.13
SV200	100	100	1200.00 ± 0.00^a3c2
CF100	—	16.67	660.00 ± 57.97^a1b2
CF200	33.33	50.00	880.00 ± 110.27^a3
CF400	33.33	50.00	960.00 ± 81.98^a3

Data are expressed as mean ± SEM. n = 6 mice. ^aCompared to NC; ^bcompared to SV200; ^ccompared to 100 mg/kg; ^dcompared to 200 mg/kg; ^ecompared to 400 mg/kg. ¹, ², ³. NC, group treated with distilled water (10 ml/kg); SV200, sodium valproate (200 mg/kg); AF, aqueous fraction of Pentas schimperiana (A. Rich.) Vatke; BF, butanol fraction of Pentas schimperiana (A. Rich.) Vatke; CF, chloroform fraction of Pentas schimperiana (A. Rich.) Vatke. Numbers refer to dose in mg/kg.