Evaluation of Anticonvulsant Activity of 80% Methanolic Root Bark Extract and Solvent Fractions of Pentas schimperiana (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice

Table 2

Anticonvulsant effect of solvent fraction of Pentas schimperiana (A. Rich.) Vatke root bark in MES-induced seizure.

Group	% reduction in duration of THLE	Mean duration of THLE (S)
NC	—	30.33 ± 4.12
PTN25	93.41	2.00 ± 1.26^a3c3d3e3
AF100	1.65	29.83 ± 1.45^b3
AF200	7.68	28.00 ± 1.39^b3
AF400	9.33	27.50 ± 1.77^b3
NC	—	30.33 ± 4.12
PTN25	93.41	2.00 ± 1.26^a3c3d3e3
BF100	18.67	24.67 ± 1.86^b3e2
BF200	35.15	19.67 ± 2.26^a1b3
BF400	54.40	13.83 ± 1.78^a3b2c2
NC	—	30.33 ± 4.12
PTN25	93.41	2.00 ± 1.26^a3c3d3e3
CF100	1.65	29.83 ± 1.70^b3
CF200	5.47	28.67 ± 1.58^b3
CF400	7.12	28.86 ± 1.78^b3

Data are expressed as mean ± SEM. n = 6 mice. ^aCompared to NC; ^bcompared to PTN25; ^ccompared to 100 mg/kg; ^dcompared to 200 mg/kg; ^ecompared to 400 mg/kg.¹, ², ³. NC, group treated with distilled water (10 ml/kg), PTN25, phenytoin (25 mg/kg); THLE, tonic hind limb extension; AF, aqueous fraction of Pentas schimperiana (A. Rich.) Vatke; BF, butanol fraction of Pentas schimperiana (A. Rich.) Vatke; CF, chloroform fraction of Pentas schimperiana (A. Rich.) Vatke. Numbers refer to dose in mg/kg.