Advances in Pharmacological and Pharmaceutical Sciences / 2021 / Article / Tab 1

Research Article

Evaluation of Hepatoprotective Activity of Caralluma europaea Stem Extract against CCl4-Induced Hepatic Damage in Wistar Rats

Table 1

Effect of aqueous extract of Caralluma europaea against carbon tetrachloride-induced hepatotoxicity-related parameters in rats.

Treatment (n = 6)ALT (IU/L)AST (IU/L)ALP (IU/L)Total bilirubin (mg/L)Direct bilirubin (mg/L)Total protein (g/L)

Normal control36.33 ± 4.44105.70 ± 9.7171.33 ± 31.200.65 ± 0.111.00 ± 0.0060.15 ± 0.93
CCl4 (1 mL/kg )1014.33 ± 87.001189.83 ± 114.53486.50 ± 34.844.45 ± 0.493.83 ± 0.4738.71 ± 2.37
CCl4 + AECe (250 mg/kg)668.20 ± 22.14Ns891.83 ± 32.33Ns245.33 ± 18.81Ns2.60 ± 0.26 Ns2.50 ± 0.22 ††55.68 ± 1.17Ns
AECe (250 mg/kg)35.83 ± 5.5297.83 ± 5.09148.70 ± 17.530.75 ± 0.141.16 ± 0.1660.06 ± 1.32
CCl4 + silymarin (40 mg/kg)640.00 ± 39.83 702.16 ± 55.59 335.83 ± 23.53 1.78 ± 0.201.16 ± 0.1658.08 ± 1.54

Values are expressed as mean ± SEM, (n = 6). Data were analyzed by one-way ANOVA followed by Tukey’s test.  when compared to the normal control group;  when compared to the normal control group.  when compared to the CCl4 group;  when compared to the CCl4 group;  when compared to the CCl4 group. Ns = not significant when compared to the CCl4 + silymarin group; ††p < 0.01 when compared to the CCl4 + silymarin group.