Evaluation of Hepatoprotective Activity of Caralluma europaea Stem Extract against CCl₄-Induced Hepatic Damage in Wistar Rats

Table 1

Effect of aqueous extract of Caralluma europaea against carbon tetrachloride-induced hepatotoxicity-related parameters in rats.

Treatment (n = 6)	ALT (IU/L)	AST (IU/L)	ALP (IU/L)	Total bilirubin (mg/L)	Direct bilirubin (mg/L)	Total protein (g/L)
Normal control	36.33 ± 4.44	105.70 ± 9.7	171.33 ± 31.20	0.65 ± 0.11	1.00 ± 0.00	60.15 ± 0.93
CCl4 (1 mL/kg )	1014.33 ± 87.00	1189.83 ± 114.53	486.50 ± 34.84	4.45 ± 0.49	3.83 ± 0.47	38.71 ± 2.37
CCl4 + AECe (250 mg/kg)	668.20 ± 22.14^Ns	891.83 ± 32.33^Ns	245.33 ± 18.81^Ns	2.60 ± 0.26 ^Ns	2.50 ± 0.22 ^††	55.68 ± 1.17^Ns
AECe (250 mg/kg)	35.83 ± 5.52	97.83 ± 5.09	148.70 ± 17.53	0.75 ± 0.14	1.16 ± 0.16	60.06 ± 1.32
CCl4 + silymarin (40 mg/kg)	640.00 ± 39.83	702.16 ± 55.59	335.83 ± 23.53	1.78 ± 0.20	1.16 ± 0.16	58.08 ± 1.54

Values are expressed as mean ± SEM, (n = 6). Data were analyzed by one-way ANOVA followed by Tukey’s test.  when compared to the normal control group;  when compared to the normal control group.  when compared to the CCl₄ group;  when compared to the CCl₄ group;  when compared to the CCl₄ group. Ns = not significant when compared to the CCl₄ + silymarin group; ^††p < 0.01 when compared to the CCl₄ + silymarin group.