Antimalarial, Antioxidant Activities and Chemoprofile of Sansevieria liberica Gerome and Labroy (Agavaceae) Leaf Extract
Table 1
Curative effect of 90% methanolic leaf extract of SL in established infection (Rane assay).
Drug
Dose mg/kg
Parasitemia
Day 3
Day 4
Day 5
Day 6
Day 7
Day 8
MST (Days)
5% DMSO
0.2 ml
% parasitemia
11.31 ± 0.28
13.49 ± 1.04
15.38 ± 0.64
18.3 0 ± 0.42
20.47 ± 0.34
16.31 ± 0.51
8.43
% inhibition
0
0
0
0
0
0
CQ
10
% parasitemia
11.66 ± 0.32
10.70 ± 0.84
4.38 ± 0.68
1.39 ± 0.24
0 ± 0
0 ± 0
21∗
% inhibition
-3.09
20.68
71.52
92.40
100
100
SL
100
% parasitemia
10.61 ± 0.00
11.84 ± 0.00
10.44 ± 0.00
9.01 ± 0.00
7.75 ± 0.00
6.16 ± 0.00
21∗
% inhibition
6.19
12.23
31.99
50.77
62.14
71.09∗
200
% parasitemia
10.86 ± 0.00
12.26 ± 0.00
10.59 ± 0.00
9.04 ± 0.00
7.47 ± 0.00
5.84 ± 0.00
21∗
% inhibition
3.98
9.12
31.01
50.60
63.51
72.60∗
400
% parasitemia
11.35 ± 0.00
12.62 ± 0.00
11.13 ± 0.00
8.81 ± 0.00
6.91 ± 0.00
7.76 ± 0.00
14.36∗
% inhibition
-0.35
6.45
27.49
51.86
66.24
62.09∗
Values for mean % parasitemia are expressed as mean ± standard error of the mean (± SEM) n = 5, significant at when compared with the control. SL: Sansevieria liberica extract; CQ: chloroquine; MST: mean survival time (days).
