Research Article

In Silico, In Vitro, and In Vivo Wound Healing Activity of Astragalus microcephalus Willd.

Table 2

Flavonoids present in the extract and their affinity to binding to the ERs α and β.

LigandER α (Kcal/mol)ER β (Kcal/mol)

Estradiol−7.7 to −6.7−7.5 to −6.4
Finasteride−7 to −6.8−8.2 to −6.6
Formononetin−7.2 to−6.4−8 to −6.2
Kaempferol-3-O-glucoside−7.9 to −6.9−8.5 to −7.1
Kaempferol-3-O-sophoroside−7.4 to −6.7−8.0 to −7.4
Kaempferol-3-O-neohesperidoside−7.9 to −7.3−7.3 to −6.8
Quercetin-3-O-neohesperidoside−7.8 to −6.8−7.9 to−7.3
Calycosin-7-O-beta-D-glucoside−7.6 to −7−7.7 to −7.2

Molecular docking results indicated that all ligands had a high affinity (<−6.3) to receptors.