Antidiabetic Properties and Toxicological Assessment of Antidesma celebicum Miq: Ethanolic Leaves Extract in Sprague–Dawley Rats

Table 7

Hematological and biochemical values for rats treated with EEAC in acute toxicity study.

Parameter	Dose (mg/kg BW)
	0	300	2000	5000
Male
RBC (×10^6/µl)	7.10 ± 0.38	7.56 ± 0.28	7.42 ± 0.20	7.70 ± 0.38
HGB (mg/dl)	13.98 ± 0.55	14.68 ± 0.41	14.64 ± 0.50	14.56 ± 0.58
Hematocrit (%)	38.20 ± 1.59	42.60 ± 1.25	41.20 ± 0.97	40.80 ± 1.20
MCV (fl)	54.10 ± 0.61	56.40 ± 1.86	55.40 ± 0.98	53.40 ± 1.78
MCH (pg)	19.82 ± 0.39	19.40 ± 0.51	19.60 ± 0.24	18.80 ± 0.49
MCHC (g/dl)	36.64 ± 0.35	34.40 ± 0.68	34.80 ± 0.86	35.60 ± 0.68
WBC (×10^3/µl)	7.38 ± 0.48	7.94 ± 0.87	8.52 ± 0.79	7.42 ± 1.12
AST (I/U)	156.20 ± 3.80	136.20 ± 12.76	200.2 ± 33.98	172.00 ± 20.08
ALT (I/U)	64.28 ± 6.38	55.80 ± 4.18	59.00 ± 3.62	54.00 ± 6.67
Urea (mg/dl)	32.80 ± 3.52	48.72 ± 1.62	43.56 ± 1.95	48.14 ± 2.35
Creatinine (mg/dl)	0.52 ± 0.05	0.68 ± 0.04	0.64 ± 0.03	0.62 ± 0.04
Female
RBC (×10^6/µl)	6.84 ± 0.24	6.84 ± 0.23	6.32 ± 0.31	6.94 ± 0.29
HGB (mg/dl)	13.76 ± 0.59	13.74 ± 0.34	12.80 ± 0.40	13.62 ± 0.36
Hematocrit (%)	38.60 ± 1.81	37.60 ± 1.29	36.40 ± 1.60	39.00 ± 1.18
MCV (fl)	56.18 ± 0.66	54.80 ± 1.39	58.00 ± 2.37	56.20 ± 1.20
MCH (pg)	20.10 ± 0.41	20.20 ± 0.49	20.40 ± 0.75	19.60 ± 0.40
MCHC (g/dl)	35.80 ± 0.48	37.00 ± 0.77	35.20 ± 0.58	35.20 ± 0.20
WBC (×10^3/µl)	5.82 ± 0.30	6.84 ± 0.76	6.82 ± 0.72	5.46 ± 0.61
AST (I/U)	103.60 ± 9.63	141.80 ± 16.30	96.40 ± 2.21	111.60 ± 16.92
ALT (I/U)	49.92 ± 11.55	54.80 ± 4.55	48.60 ± 2.68	47.40 ± 2.86
Urea (mg/dl)	30.60 ± 1.65	43.92 ± 0.76	45.04 ± 1.72	41.46 ± 4.22
Creatinine (mg/dl)	0.64 ± 0.09	0.80 ± 0.03	0.60 ± 0.03	0.66 ± 0.04

RBC: red blood cell count, HGB: hemoglobin, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, WBC: white blood cell count, AST: aspartate aminotransferase, ALT: alanine aminotransferase. Data are means ± SEM for groups of five rats/sex/dose vs. control group.