Formulation Design and Cell Cytotoxicity of Curcumin-Loaded Liposomal Solid Gels for Anti-Hepatitis C Virus

Table 1

Cell cytotoxicity (CC₅₀) of CUR-loaded liposomal solid gels, determined by the incubation of a series of sample concentrations to reach 50% of cells that remain viable.

Concentration (μg/mL)	Viability (%)
	S-PC Lip/SolGel^a	E-PC Lip/SolGel^b	HS-PC Lip/SolGel^c
0.7 × 10^3	96.1 ± 0.04	95.7 ± 0.01	97.7 ± 0.01
1.5 × 10^3	95.6 ± 0.01	95.0 ± 0.01	97.3 ± 0.02
3.0 × 10^3	92.3 ± 0.01	92.3 ± 0.02	96.8 ± 0.002
6.0 × 10^3	90.5 ± 0.01	91.7 ± 0.03	93.5 ± 0.01
12.0 × 10^3	88.8 ± 0.01	85.9 ± 0.02	85.9 ± 0.01
25.0 × 10^3	81.3 ± 0.05	73.9 ± 0.02	46.3 ± 0.01

Notes: ^aCC₅₀ = 79 × 10³ μg/ml; ^bCC₅₀ = 52 × 10³ μg/ml; ^cCC₅₀ = 25 × 10³ μg/ml. CC₅₀ was calculated by extrapolating the percent viability data at 50% to the corresponding concentration. Abbreviations: S-PC Lip/SolGel. soy phosphatidylcholine liposomal solid gel; E-PC Lip/SolGel. egg phosphatidylcholine liposomal solid gel; HS-PC Lip/SolGel. hydrogenated-soy phosphatidylcholine liposomal solid gel.