Passiflora mollissima Seed Extract Induced Antiproliferative and Cytotoxic Effects on CAL 27 Spheroids

Figure 4

Histological changes of spheroid with H&E staining. It was shown the effect of PME (10, 50, and 100 μg/ml) and 20 μM of cisplatin drug at 72 hours on spheroid morphology. Viable cells with high proliferation and high DNA concentration are dark pink, and necrotic cells show light pink. Scale bar: 20 μm.