Current Trends on Solid Dispersions: Past, Present, and Future

Table 4

Shows examples of decent case studies for the preparation of solid dispersion using the fusion method.

Drug name	Solubility of the pure drug (mg/L) at 25°C	Solubility of the solid dispersed drug at 25°C	Drug release of the pure drug at 37°C after an hour	Drug release percentage of the solid dispersed drug at 37°C after an hour	Polymer used	Reference
Spironolactone	0.02354	0.06173	27.25	74.24	Polyethene glycol 4000	[29]
Carvedilol	0.002	0.012	42.6	93.214	Poloxamer 188	[30]
Cefuroxime axetil	0.412	5.886	10	92	Poloxamer 188	[31]
Luteolin	1.93 × 10^−5 (at 20°C)	—	13.11	97.78	Polyethylene glycol 4000	[32]
Atorvastatin	<1	—	60	99	Polyethylene glycol 6000	[33]