Advances in Pharmacological and Pharmaceutical Sciences

Research Article

Phytochemical Analysis and Antifungal Potentiating Activity of Extracts from Loquat (Eriobotrya japonica) against Cryptococcus neoformans Clinical Isolates

Table 3

Effect of the combination of methanol extract of seeds (MeS) and hexane extract of leaves (HeL) with nystatin and clotrimazole.


	MeS + nystatin		MeS + clotrimazole		HeL + nystatin		HeL + clotrimazole
	MIC reduction fold	FICI (interpretation)	MIC reduction fold	FICI (interpretation)	MIC reduction fold	FICI (interpretation)	MIC reduction fold	FICI (interpretation)

CN	8	0.13 (Syn)	4	0.25 (Syn)	8	0.13 (Syn)	4	0.25 (Syn)
CN169	4	0.27 (Syn)	32	0.03 (Syn)	32	0.03 (Syn)	4	0.27 (Syn)
CN173	16	0.06 (Syn)	0.5	2.01 (Ind)	16	0.06 (Syn)	2	0.50 (Ind)
CN047	4	0.28 (Syn)	2	0.53 (Syn)	4	0.25 (Syn)	0.25	4.02 (Ant)
CN091	2	0.25 (Syn)	0.5	4.02 (Ant)	4	0.25 (Syn)	0.125	8.06 (Ant)
CN165	16	0.07 (Syn)	8	0.13 (Syn)	0.25	6.00 (Ant)	4	0.31 (Syn)
CN118	4	0.25 (Syn)	4	0.25 (Syn)	4	0.28 (Syn)	0.25	4.50 (Ant)
CN46	32	0.04 (Syn)	0.5	2.06 (Ind)	4	0.50 (Ind)	0.5	2.25 (Ind)
CN96	4	0.26 (Syn)	0.25	4.13 (Ant)	4	0.25 (Syn)	2	0.51 (Ind)

Syn, synergistic; Ind, indifferent; Ant, antagonistic.