Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Table 3

Anti-inflammatory activity of D. microcarpum.

S/N	Method	Solvents	Part of the plant	Major findings	Reference
1	In Vivo	n-hexane, ethylacetate, methanol, and aqueous	Leaf	Methanolic leaves extract showed the highest acute inflammatory activity at	[61]
2	In Vivo	Methanol	Stem bark	When injected intraperitoneally in mice, the LD50 of the extract was 471.2 mg/kg body weight and ≥5000 mg/kg body weight. The methanolic extract reduced the mean diameter of the rat paw in carrageenan-induced inflammation when compared to the normal saline-treated group.	[62]
3	Egg albumin, formalin induced inflammation	Methanol	Leaf	The results indicate that the methanol leaf extract exhibits considerable dose-dependent anti-inflammatory action against egg albumin and formalin-induced inflammation at . At doses of 200 and 400 mg/kg, the extract inhibited egg albumin by 26.5 and 29.4%, respectively, at the 5th hour. For all doses 200 and 400 mg/kg, the % inhibition of formalin-induced edema was 32.5.	[63]
4	IN Vivo	n-Hexane, ethylacetate, methanol, and aqueous	Leaf	Methanolic leaves extract showed the highest inhibition analgesic activity at 88%	[61]
5	In Vivo	Aqueous	Stem bark	Plasma activity was significantly lower in the groups treated with the extract at . In the same group, a low plasma level of total protein was also detected. As a result, oral administration of the aqueous bark extract demonstrated antiatherogenic, cardioprotective, and hepatoprotective activity.	[64]

Notes: S/N = serial number and LD₅₀ = lethal dose.