Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review
Table 6
Antiparasitic activity of D. microcarpum.
S/N
Method
Solvents
Part of the plant
Major findings
Reference
1
Antiparasitic
Methanol
Stem bark
For the 200, 400, and 800 mg/kg tested doses, the methanolic stem bark extract had a significant () curative as well as prophylactic impact, and the survival period of mice was significantly () extended in the treated groups. There was no effect of the extract on the biochemical and haematological tests at .
When compared to the negative control, the methanolic leaf extract significantly reduced the average % of parasitemia level in the treatment group. At doses of 250, 500, and 1000 mg/kg, the extract cleared parasites at 83.52, 86.65, and 87.21%, respectively.
After 14 days of treatment, both doses of the extract administered significantly reduced parasitemia. On the other hand, neither dose of the extract reversed trypanosome-induced anaemia. Similarly, the extract was unable to improve hepatomegaly and splenomegaly caused by trypanosomes.
The observed result indicated that the methanolic leaf extract possesses trypano suppressive action, implying that it may be employed as a candidate for the development of medications to treat disorders caused by trypanosomes.
The methanolic leaf extract’s of oral LD50 was determined to be greater than 5000 mg/kg. At all doses examined, the extract had substantial curative, suppressive, and preventive effects at . Additionally, the extract increased the survival period of treated mice by up to 19 days when compared to the negative control group.
Both the aqueous and methanolic stem bark extracts inhibited larval mobility in C. elegans, Bristol, and C. elegans DA1316 with a significant difference at compared to the negative control.
At a concentration of 10 μM, the extract displayed strong inhibitory potency of 83.87 against hepatitis C virus, compared to control (RS446 (2-Me-C) at 86.76% respectively.
