Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol

Table 4

Evaluation of oxidative damage by estragole in proficient and deficient strains of Saccharomyces cerevisiae.

Treatments	Strains
	SODWT	Sod1∆	Sod2∆	Sod1∆Sod2∆	Cat1∆	Sod1∆Cat1∆
Saline 0.9%	0.75 ± 0.47	1.75 ± 0.70	0.50 ± 0.28	2.75 ± 1.59	0.50 ± 0.37	1.25 ± 0.50
DMSO 0.05%	0.75 ± 0.47	0.75 ± 0.47	0.9 ± 0.28	0.8 ± 0.32	1.1 ± 0.54	0.5 ± 0.15
H2O2 10 mM	30.75 ± 5.0^∗∗	25.50 ± 4.2^∗∗	25.25 ± 6.18^∗∗	27.00 ± 5.09^∗∗	24.25 ± 4.03^∗∗	22.2 ± 4.57^∗∗
Estragole
0.9 μg/mL	2.00 ± 0.54	2.00 ± 1.41	3.00 ± 1.41	3.50 ± 0.70	3.00 ± 1.41	3.50 ± 0.70
1.8 μg/mL	1.50 ± 0.70	1.50 ± 0.70	3.50 ± 0.70	3.50 ± 0.70	4.50 ± 0.70	4.00 ± 2.82
3.6 mg/mL	1.00 ± 1.41	2.50 ± 0.70	2.00 ± 0.54	2.50 ± 0.70	4.00 ± 1.41	4.00 ± 1.41
7.2 μg/mL	2.00 ± 1.41	2.00 ± 1.41	2.00 ± 0.54	2.50 ± 0.70	1.50 ± 2.12	3.50 ± 0.70
14.4 μg/mL	2.50 ± 0.70	2.00 ± 0.54	3.50 ± 0.70	3.50 ± 0.70	4.50 ± 2.12	5.00 ± 0.0
32 μg/mL	2.00 ± 0.54	2.50 ± 0.70	2.00 ± 0.54	2.50 ± 0.70	3.00 ± 1.41	4.50 ± 0.70
64 μg/mL	2.00 ± 0.54	2.50 ± 0.70	3.50 ± 0.70	1.50 ± 0.70	7.00 ± 1.41^∗	3.00 ± 1.41
128 μg/mL	1.50 ± 0.70	2.50 ± 0.70	3.50 ± 0.70	3.00 ± 1.41	2.50 ± 0.70	4.50 ± 2.12
256 mg/mL	3.50 ± 0.70	2.50 ± 0.70	2.50 ± 0.70	2.50 ± 2.12	3.00 ± 1.41	3.00 ± 2.82
500 mg/mL	1.50 ± 0.70	1.50 ± 0.70	3.00 ± 1.41	2.50 ± 0.70	4.50 ± 0.70	3.50 ± 0.70

Notes. Values are mean ± SD. Two-way ANOVA, Tukey post-hoc test. ^∗ and ^∗∗ compared to saline solution.