Research Article
Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol
Table 5
Evaluation of oxidative damage by 3,7-dimethyl-1-octanol in proficient and deficient strains of Saccharomyces cerevisiae.
| Treatments | Strains | SODWT | Sod1∆ | Sod2∆ | Sod1∆Sod2∆ | Cat1∆ | Sod1∆Cat1∆ |
| Saline 0.9% | 0.75 ± 0.47 | 1.75 ± 0.70 | 0.50 ± 0.28 | 2.75 ± 1.59 | 0.50 ± 0.37 | 1.25 ± 0.50 | DMSO 0.05% | 0.75 ± 0.47 | 0.75 ± 0.47 | 0.9 ± 0.28 | 0.8 ± 0.32 | 1.1 ± 0.54 | 0.5 ± 0.15 | H2O2 10 mM | 30.75 ± 5.0∗∗ | 25.5 ± 4.2∗∗ | 25.25 ± 6.18∗∗ | 27.00 ± 5.09∗∗ | 24.25 ± 4.03∗∗ | 22.25 ± 4.57∗∗ |
| 3,7-Dimethyl-1-octanol | 0.9 μg/mL | 1.50 ± 0.70 | 0.50 ± 0.70 | 1.50 ± 0.70 | 1.50 ± 0.70 | 2.50 ± 0.70 | 2.50 ± 0.70 | 1.8 μg/mL | 1.50 ± 0.70 | 0.00 ± 0.00 | 2.00 ± 0.00 | 1.00 ± 1.41 | 3.50 ± 0.70 | 3.00 ± 0.00 | 3.6 mg/mL | 2.00 ± 0.00 | 1.50 ± 0.70 | 2.50 ± 0.70 | 2.00 ± 1.41 | 2.50 ± 0.70 | 4.00 ± 1.41 | 7.2 μg/mL | 2.50 ± 0.70 | 1.00 ± 0.00 | 2.50 ± 0.70 | 2.50 ± 0.70 | 4.00 ± 0.00 | 3.00 ± 1.41 | 14.4 μg/mL | 2.00 ± 1.41 | 1.00 ± 1.41 | 1.50 ± 0.70 | 2.00 ± 0.00 | 3.50 ± 0.70 | 2.00 ± 2.82 | 32 μg/mL | 2.00 ± 0.00 | 2.50 ± 0.70 | 3.00 ± 0.00 | 2.50 ± 0.70 | 3.50 ± 2.12 | 3.50 ± 0.70 | 64 μg/mL | 1.50 ± 0.70 | 3.00 ± 0.00 | 1.00 ± 0.00 | 3.50 ± 0.70 | 3.50 ± 0.70 | 3.00 ± 1.41 | 128 μg/mL | 1.00 ± 1.41 | 1.50 ± 0.70 | 1.50 ± 0.70 | 3.50 ± 0.70 | 3.50 ± 2.12 | 4.00 ± 1.41 | 256 mg/mL | 0.50 ± 0.70 | 2.50 ± 0.70 | 1.00 ± 1.41 | 3.00 ± 1.41 | 2.50 ± 2.12 | 3.00 ± 0.00 | 500 mg/mL | 2.50 ± 0.70 | 3.00 ± 0.00 | 2.50 ± 0.70 | 2.50 ± 0.70 | 3.00 ± 1.41 | 3.50 ± 0.70 |
|
|
Notes. Values are mean ± SD. Two-way ANOVA, Tukey post-hoc test. ∗∗ compared to saline solution. |