Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety

Figure 3

Upregulation and activation of SIRT1 in the liver by kaempferol. The SIRT1 deacetylase activity and expression increases, which leads to inhibition of several transcription factors, such as inflammation, mitochondrial dysfunction, apoptosis, and radical superoxide, in the liver tissue. Inhibition (⟞).