Review Article

Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review

Table 1

Ethnomedicinal use of C. arvensis.

Area of studyUse partMode of preparationTraditional useReferences

The Khattak tribe of Chonthra Karak (Pakistan)FlowersPowderStrengthen eyesight, treat heart disease and heal wounds[52]
Upper Dir, Khyber Pakhtunkhwa (Pakistan)Root and leavesPoulticeTreat eye disorders, oral sore, and inflammation[53]
The tribal population of the north-west Frontier Province (Pakistan)LeavesCrushedWound healing[54]
District Attock (Pakistan)FlowersStrengthen eyesight, treat heart disease, and promote skin healing[55]
Madyan Valley in district Swat (Pakistan)Leaves and flowersUsed as an anthelmintic, tonic, and diaphoretic[56]
Jatlan Azad Jammu, Kashmir (Pakistan)DecoctionUsed as a diaphoretic and antiemetic.
Treat digestive ailments
[57]
Karak, Khyber Pakhtunkhwa (Pakistan)Leaves and flowersTreat toothache[58]
Malam Jabba Valley of Swat (Pakistan)Leaves and flowersUsed as a tonic, diaphoretic, and anthelmintic[37]
The Alaşehir and its surrounding (Manisa/Turkey)Aerial partsInfusion, mash, and medical oilTreated skin cancer.
Used in burn care
[32, 33]
Erzincan (Turkey)FlowersDecoctionUsed as a hepatoprotector, germicide, and fungicide[34]
Yaslıca Town and Arıkök neighborhood in the Bozova district of Şanlıurfa province (Turkey)FlowersDecoctionFungal treatment[24]
Targuist area (North of Morocco)FlowersCataplasmUsed as an anti-inflammatory and antiseptic[14]
The Tiaret Mountains (Western Algeria)Used as a depurative, emmenagogue, antispasmodic, and stimulant of hepatic activity and bile secretion[59]
The Mountains Tessala (Western Algeria)FlowersInfusionUsed as a depurative, emmenagogue, antispasmodic, and stimulant of hepatic activity and bile secretion[60]
LeavesMacerationCalm vomiting and internal ulcers
Erase warts, calluses body, fistula, frostbite, and skin lesions
The Moroccan RifFlowersInfusionTreat diabetes[16]
Aguelmouss (Khenifra,
Morocco)
Wound healing[26]
Sardinia (Italy)LeavesTeas or decoctionUsed as an emmenagogue, diaphoretic, diuretic, sedative, anti-inflammatory[31]
Aguelmouss, Khenifra Province (Morocco)Treated neurological, microbial affections, ENT, and typhoid diseases[17]
The Canary islands (Spanish)Aerial partsUsed as an emmenagogue and aperitive[27]
Rabat-Sale-Kenitra Regions (Morocco)Leaves and flowersDecoctionTreat diabetes[15]
The Mt. Pelion Area (Greece)Leaves, stems, and flowersTreat acne and diaper rash[61]
The Mainarde Mountains (Central-Southern Apennine, Italy)Macerated and ointmentTreat burns, sunburn, chilblains, joint pain, and stings[62]
Western Gironès (Catalonia, Iberian Peninsula)Aerial partsBathOcular antiseptic[29]
The mountains of Tlemcen (Western Algeria)Disinfectant and antihemorrhagic
Treat influenza, transpiration, and hemostatic action
[63]
District Swat (Pakistan)Leaves and flowersUsed as scrofula, diaphoretic, antihelminthic, and tonic[64]
Swat Valley (Pakistan)Leaves and flowersPowderUsed as scrofula, tonic, diaphoretic, anthelmintic
Treat mucus discharge
[65, 66]
Swat (Pakistan)Flower and leavesShootUsed as stimulant, antispasmodic, and astringent.
Treat wounds and injuries
[67]
Gujranwala Region, Punjab (Pakistan)Leaves and flowersExtractSevere pains[68]
Oulad Daoud Zkhanine (Nador Province, Morocco)Whole plantDecoctionTreat digestive disorders.
Used for hair care
[19]
Kohistan Valley, Khyber Pakhtoonkhwa (Pakistan)FlowersStrengthen eyesight.
Treated heart and skin diseases
[69]
Thz M’Zab valley (Algeria)FlowersInfusionTreat high blood pressure[20]
Sawans Valley Mianwali, Punjab (Pakistan)Wound healing[70]
The Talash Valley of Dir Lower (Pakistan)FlowersJuiceTreat toothache[71]
Syria's western region (Tartus and Latakia)Aerial partsInfusionTreat varicose veins, sore eyes, wounds, sprains, bites and stings, and skin problems[72]
The villages of Lotzorai and Escolca (Sardinia, Italy)FlowersInfusion and cataplasmUsed as an antispasmodic
Treat burns
[22]
The Taza region (Morocco)Stems and flowersDecoctionTreat diabetes[25]
Tehsil Razzar District Swabi (Pakistan)Leaves and flowersDecoction in oilTreat rheumatic diseases[21]
Calabria Region (Southern Italy)Flower headsDecoctionTreat wounds, contusions, and burns[30]
Muzaffarabad, Azad Jammu, and Kashmir (Pakistan)Leaves and flowersUsed as astringent, expectorant, and antispasmodic.
Treat varicose veins
[35]
Bosnia and HerzegovinaFlowersInfusion and decoctionTreat lung cancer and
treat liver and skin diseases
[73]
The Ripollès district (Spain)InflorescencesLinimentUsed as antiecchymotic[28]
Alaşehir (Manisan Turkey)Aerial partsInfusion, maceration, and oilTreat skin cancer
and treat burns
[33]
Sarigöl district (Manisa, Turkey)Aerial partsInfusion, mash, and lotionTreat sores, burns, skin cancers, and athletes’ feet[32]
The Bissa region (Northeastern Dahra Mountains, Algeria)Leaves and rootsDecoction and infusionTreat rheumatism[74]
Malam Jabba, Swat (Pakistan)Leaves and flowersUsed as a tonic, diaphoretic, and anthelmintic[18]
Chagharzai Valley, District Buner (Pakistan)Leaves and shootsTreat skin diseases[75]
Margalla Hills National Park, Islamabad (Pakistan)Leaves and flowersUsed as an antispasmodic, emmenagogue, and wound healing[36]
Azad Jammu And Kashmir state (Pakistan)All partsDecoctionTreat diaphoretic and antiemetic disorders[23]
Mihalgazi (Eskişehir, Turkey)Leaves and capitulumPoulticeTreat skin diseases[76]
South-West of PakistanLeaves and stemInfusionTreat diabetes[77]