Research Article
Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties
Table 1
Theoretical composition, drug-to-polymer-to-surfactant ratio, and manufacturing process.
| Drug : PEG : SLS | Manufacturing process | Formulation code |
| 1 : 0 : 0 | — | Glyburide | 1 : 3 : 1 | Fusion | F1 | 1 : 5 : 1 | Fusion | F2 | 1 : 9 : 1 | Fusion | F3 | 1 : 3 : 1 | Solvent evaporation | SE1 | 1 : 5 : 1 | Solvent evaporation | SE2 | 1 : 9 : 1 | Solvent evaporation | SE3 | 1 : 3 : 1 | Physical mixing | PM1 | 1 : 5 : 1 | Physical mixing | PM2 | 1 : 9 : 1 | Physical mixing | PM3 |
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