Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties

Table 1

Theoretical composition, drug-to-polymer-to-surfactant ratio, and manufacturing process.

Drug : PEG : SLS	Manufacturing process	Formulation code
1 : 0 : 0	—	Glyburide
1 : 3 : 1	Fusion	F1
1 : 5 : 1	Fusion	F2
1 : 9 : 1	Fusion	F3
1 : 3 : 1	Solvent evaporation	SE1
1 : 5 : 1	Solvent evaporation	SE2
1 : 9 : 1	Solvent evaporation	SE3
1 : 3 : 1	Physical mixing	PM1
1 : 5 : 1	Physical mixing	PM2
1 : 9 : 1	Physical mixing	PM3