Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties

Table 3

Dissolution efficiency (DE) and mean dissolution time (MDT) of the pure glyburide and related formulations (right after and after 12-month storage).

Formulation code	DE (%)	MDT (min)
Glyburide	22.88 ± 8.11	50.91 ± 16.82
PM3	73.13 ± 17.13	29.37 ± 9.25
F1	85.43 ± 16.75	17.48 ± 5.16
F1–12	82.65 ± 17.46	20.82 ± 5.16
F2	93.43 ± 13.38	7.88 ± 1.17
F2–12	92.41 ± 13.85	9.11 ± 5.16
F3	94.49 ± 11.22	6.61 ± 0.66
F3–12	93.37 ± 12.31	7.95 ± 5.16
SE1	85.53 ± 16.38	17.37 ± 5.35
SE1–12	83.44 ± 18.28	19.87 ± 5.16
SE2	93.75 ± 12.75	7.50 ± 1.02
SE2–12	92.75 ± 13.62	8.70 ± 5.16
SE3	95.87 ± 9.29	5.00 ± 00
SE3–12	95.51 ± 9.62	5.39 ± 5.16

Results are presented as mean ± standard deviation (n = 3).