Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties

Table 4

Investigation of drug release percentage from solid dispersions prepared by F (fresh and after 12-month storage).

Formulation code	F3		F2		F1
Time	After 12 months	Fresh	After 12 months	Fresh	After 12 months	Fresh
10	76.37 ± 6.63	83.87 ± 6.08	68.19 ± 5.19	71.60 ± 6.08	44.32 ± 1.19	49.78 ± 3.24
20	94.10 ± 4.67	100 ± 5.85	90.69 ± 3.84	99.56 ± 5.64	61.37 ± 4.12	67.51 ± 4.74
30	100 ± 4.87	100 ± 5.64	100 ± 4.29	100 ± 5.40	73.64 ± 5.40	79.10 ± 5.64
45	100 ± 6.63	100 ± 6.08	100 ± 4.74	100 ± 5.40	83.87 ± 5.40	89.33 ± 5.64
60	100 ± 5.45	100 ± 5.01	100 ± 4.74	100 ± 5.64	98.19 ± 5.40	100 ± 5.85
120	100 ± 4.34	100 ± 4.67	100 ± 4.12	100 ± 5.19	100 ± 4.70	100 ± 5.01

Results are presented as mean ± standard deviation (n = 3).