Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties

Table 5

Investigation of drug release percentage from solid dispersions prepared by SE (fresh and after 12-month storage).

Formulation code	SE3		SE2		SE1
Time	After 12 months	Fresh	After 12 months	Fresh	After 12 months	Fresh
10	96.15 ± 3.57	100 ± 3.15	69.55 ± 2.06	75.01 ± 5.64	45.0 ± 4.74	52.51 ± 2.25
20	100 ± 4.12	100 ± 2.74	93.42 ± 1.96	100 ± 5.30	55.91 ± 5.19	66.14 ± 3.24
30	100 ± 3.68	100 ± 2.34	100 ± 3.15	100 ± 3.68	72.28 ± 4.50	75.69 ± 5.40
45	100 ± 3.15	100 ± 5.30	100 ± 4.76	100 ± 3.15	90.01 ± 5.41	92.05 ± 5.40
60	100 ± 4.34	100 ± 5.01	100 ± 3.12	100 ± 3.15	100 ± 5.63	100 ± 5.85
120	100 ± 2.34	100 ± 3.68	100 ± 2.38	100 ± 3.12	100 ± 5.90	100 ± 5.01

Results are presented as mean ± standard deviation (n = 3).