Research Article
Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties
Table 5
Investigation of drug release percentage from solid dispersions prepared by SE (fresh and after 12-month storage).
| Formulation code | SE3 | SE2 | SE1 | Time | After 12 months | Fresh | After 12 months | Fresh | After 12 months | Fresh |
| 10 | 96.15 ± 3.57 | 100 ± 3.15 | 69.55 ± 2.06 | 75.01 ± 5.64 | 45.0 ± 4.74 | 52.51 ± 2.25 | 20 | 100 ± 4.12 | 100 ± 2.74 | 93.42 ± 1.96 | 100 ± 5.30 | 55.91 ± 5.19 | 66.14 ± 3.24 | 30 | 100 ± 3.68 | 100 ± 2.34 | 100 ± 3.15 | 100 ± 3.68 | 72.28 ± 4.50 | 75.69 ± 5.40 | 45 | 100 ± 3.15 | 100 ± 5.30 | 100 ± 4.76 | 100 ± 3.15 | 90.01 ± 5.41 | 92.05 ± 5.40 | 60 | 100 ± 4.34 | 100 ± 5.01 | 100 ± 3.12 | 100 ± 3.15 | 100 ± 5.63 | 100 ± 5.85 | 120 | 100 ± 2.34 | 100 ± 3.68 | 100 ± 2.38 | 100 ± 3.12 | 100 ± 5.90 | 100 ± 5.01 |
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Results are presented as mean ± standard deviation (n = 3).
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