Research Article
Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties
Table 6
Flowability and compressibility index of the untreated drug as well as prepared formulations.
| Formulation code | Compressibility index (%) (Carr’s index) | Hausner ratio | Type of flow |
| Glyburide | 37.94 ± 0.07 | 1.54 ± 0.09 | Very poor | PM3 | 32.94 ± 0.08 | 1.49 ± 0.0 | Very poor | F1 | 27.14 ± 0.18 | 1.37 ± 0.0 | Poor | F2 | 30.06 ± 0.68 | 1.42 ± 0.0 | Poor | F3 | 29.54 ± 0.65 | 1.41 ± 0.1 | Poor | SE1 | 24.75 ± 0.09 | 1.33 ± 0.1 | Passable | SE2 | 24.36 ± 0.17 | 1.32 ± 0.0 | Passable | SE3 | 23.01 ± 0.09 | 1.32 ± 0.1 | Passable |
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Results are presented as mean ± standard deviation ( n = 3). Statistically different at the significance level of 0.05 (compared to glyburide). |