Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties

Table 6

Flowability and compressibility index of the untreated drug as well as prepared formulations.

Formulation code	Compressibility index (%); (Carr’s index)	Hausner ratio	Type of flow
Glyburide	37.94 ± 0.07	1.54 ± 0.09	Very poor
PM3	32.94 ± 0.08	1.49 ± 0.0	Very poor
F1	27.14 ± 0.18	1.37 ± 0.0	Poor
F2	30.06 ± 0.68	1.42 ± 0.0	Poor
F3	29.54 ± 0.65	1.41 ± 0.1	Poor
SE1	24.75 ± 0.09	1.33 ± 0.1	Passable
SE2	24.36 ± 0.17	1.32 ± 0.0	Passable
SE3	23.01 ± 0.09	1.32 ± 0.1	Passable

Results are presented as mean ± standard deviation (n = 3). Statistically different at the significance level of 0.05 (compared to glyburide).