3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

Figure 10

Microengineered model of human pulmonary thrombosis-on-chip. (a) A conceptual schematic of the human lung showing that the alveoli interact with the neighboring blood vessels during hemostasis or pulmonary dysfunction. (b) Engineering drawing of the microdevice. (c) Graphic illustration showing how the top compartment (1 mm wide and 1 mm tall) is cultured with human primary alveolar epithelial cells and the entire bottom chamber (1 mm wide and 250 mm tall) lined with human endothelial cells forming a lumen. Reproduced (or adapted) with permission [72], ©2017, American Society for Clinical Pharmacology and Therapeutics.