3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

Figure 12

(a) Schematic showing the human intestinal epithelium and endothelium when initially plated on opposite sides of the matrix-coated porous membrane within the two-channel microfluidic device. (b) Microscopic views showing the villus morphology of the human intestinal epithelium and the immunofluorescence staining of the junction protein. (c) Microscopic views showing the planar morphology of the human endothelium and views of the immunofluorescence staining of the associated proteins. Reproduced (or adapted) with permission [84], ©2018, Nature.

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