3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

Figure 21

Ex vivo skin-on-a-chip assay for the diagnosis of skin and soft tissue infections. (a) Schematics of the human skin and blood sample loading. (b) Microfluidic design of ex vivo skin-on-a-chip. Left shows the bright field image of ex vivo skin-on-a-chip. Top-right represents the design of the migration channel (MC). Bottom-right shows the dimension of ex vivo skin-on-a-chip components: whole blood loading channel (BLC), red blood cell (RBC) filter, MC, and skin column loading channel (CLC). Reproduced (or adapted) with permission [114], ©2018, Royal Society of Chemistry.

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