3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

Figure 9

Design of the lung-on-a-chip. (a) In vivo, inspiration is controlled by the diaphragm. (b) In vitro, the 3D cyclic mechanical strain of the bioartificial alveolar membrane (A) induced by a microdiaphragm; (B) the bioartificial alveolar membrane is shown in the upper microscope picture. (c) The fluidic part consists of (i) alveolar cell culture wells, (ii) membranes, (iii) basolateral chambers, (iv) microdiaphragms, and (v) pneumatic microchannels. (d) Photograph of the lung-on-a-chip (scale bar, 10 mm). Reproduced (or adapted) with permission [69], ©2015, Royal Society of Chemistry.

(a)

(b)

(c)

(d)