3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

Table 3

Summary of recent advancements in lung-on-a-chip systems including the type of drug, the application, the applied cell lines, and kinetics.

Drug type	Application	Applied cell lines	Kinetics	Ref(s)
Gefitinib	Antitumoral drug	A549, HFL1, and HUVEC	5 days	[73]
Parmodulin-2	Antithrombotic drug	hAEC and HUVEC	12 days	[72]
Tofacitinib	Anti-inflammatory drug	hAEC	5 weeks	[67]
ZnO and TiO2 nanoparticles	Nanotoxicity	hAEC and HUVEC	3 days	[76]

A549 is an adenocarcinomic human alveolal basal epithelial cell. HFL1: human fetal lung fibroblasts; HUVECs: human umbilical cord cells; hAEC: primary human alveolar cells; ZnO: zinc oxide; TiO₂: titanium dioxide.