Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites
Table 6
Release constant (k) and regression coefficient (R2) obtained from kinetic equations reflecting LVS release from D-LSD and ID-LSD samples in pH 7.4 solution.
Sample
ZO
FO
HG
HC
KP
k
R2
k
R2
k
R2
k
R2
k
n
R2
D-LSD1
Fast stage
3.10−5
0.9281
–0.1457
0.8359
0.0001
0.9774
–1.10−5
0.9281
0.6521
0.2276
0.9825
Slow stage
6.10−7
0.9286
–0.0016
0.9315
5.10−6
0.8963
–2.10−7
0.9286
0.0307
0.8620
0.8654
D-LSD2
Fast stage
4.10−5
0.8506
–0.0898
0.7988
0.0002
0.9275
–1.10−5
0.8506
0.4051
0.3820
0.9537
Slow stage
9.10−7
0.9938
–0.0013
0.9939
8.10−6
0.9888
–3.10−7
0.9938
0.0256
0.8668
0.9785
D-LSD3
Fast stage
7.10−5
0.9278
–0.1336
0.8698
0.0003
0.9659
–2.10−5
0.9278
0.5851
0.2287
0.9821
Slow stage
2.10−6
0.9740
–0.0026
0.9729
2.10−5
0.9855
–8.10−7
0.9740
0.0517
0.7411
0.9215
ID-LSD1
Fast stage
0.0001
0.8039
–0.2226
0.8487
0.0004
0.8783
–3.10−5
0.8039
0.8007
0.0652
0.9876
Slow stage
2.10−6
0.9821
–0.0044
0.5808
2.10−5
0.982
–7.10−7
0.9821
0.1477
0.2593
0.8233
ID-LSD2
Fast stage
0.0001
0.9446
–0.1847
0.9016
0.0004
0.987
–4.10−5
0.9446
0.7243
0.1013
0.9963
Slow stage
1.10−6
0.9551
–0.0053
0.6684
10−5
0.9576
–4.10−7
0.9551
0.1549
0.4023
0.8447
ID-LSD3
Fast stage
7.10−5
0.9865
–0.1751
0.8396
0.0003
0.9894
–2.10−5
0.9700
0.7865
0.1743
0.9916
Slow stage
2.10−6
0.9618
0.0014
0.8254
2.10−5
0.9548
–6.10−7
0.9618
0.0497
0.8201
0.9460
ID-LSD4
Fast stage
0.0002
0.9283
–0.1805
0.8938
0.0007
0.9830
–5.10−5
0.9283
0.7779
0.0713
0.9994
Slow stage
4.10−6
0.9929
–0.0033
0.7872
4.10−5
0.9843
–1.10−6
0.9929
0.1160
0.3259
0.9135
ZO : zero-order kinetics; FO : first-order kinetics; HG : Higuchi model; HC : Hixson–Croswell model; KP : Korsmeyer–Peppas model.
