Influence of the Preparation Method on Some Characteristics of Alginate/Chitosan/Lovastatin Composites
Table 7
Release constant (k) and regression coefficient (R2) obtained from kinetic equations reflecting LVS release from D-LSD and ID-LSD samples in pH 2 solution.
Sample
ZO
FO
HG
HC
KP
k
R2
k
R2
k
R2
k
R2
k
n
R2
D-LSD1
Fast stage
2.10−5
0.9856
–0.0978
0.9483
0.0001
0.9942
–8.10−6
0.9856
0.4118
0.3447
0.9868
Slow stage
3.10−7
0.9286
–0.0008
0.9301
3.10−6
0.8963
–1.10−7
0.9286
0.0162
0.8855
0.8635
D-LSD2
Fast stage
5.10−5
0.9868
–0.1334
0.9369
0.0002
0.9902
–2.10−5
0.9868
0.5650
0.2384
0.9859
Slow stage
1.10−6
0.9905
–0.0018
0.9899
1.10−5
0.9970
–4.10−7
0.9905
0.0359
0.8173
0.9967
D-LSD3
Fast stage
6.10−5
0.9986
–0.1313
0.9699
0.0003
0.9759
–2.10−5
0.9986
0.5452
0.2018
0.9799
Slow stage
2.10−6
0.9506
–0.0019
0.9524
2.10−5
0.9270
–6.10−7
0.9506
0.0374
0.7619
0.9018
ID-LSD1
Fast stage
0.0001
0.9445
–0.1141
0.8909
0.0005
0.9816
–4.10−5
0.9445
0.4716
0.1201
0.9775
Slow stage
2.10−6
0.9830
–0.0012
0.7870
2.10−5
0.9794
–6.10−7
0.9830
0.0844
0.2725
0.9253
ID-LSD2
Fast stage
0.0001
0.8626
–0.1702
0.9571
0.0006
0.9365
–5.10−5
0.8626
0.6489
0.1213
0.9828
Slow stage
6.10−7
0.7560
–0.0030
0.8133
5.10−6
0.7999
–2.10−7
0.7560
0.1205
0.4222
0.9422
ID-LSD3
Fast stage
5.10−5
0.9579
–0.1698
0.9181
0.0002
0.9892
–2.10−5
0.9579
0.5584
0.3504
0.9979
Slow stage
2.10−6
0.8189
0.0063
0.7140
1.10−5
0.8602
–5.10−7
0.8189
0.0977
0.8786
0.8041
ID-LSD4
Fast stage
0.0002
0.9881
–0.1191
0.9566
0.0007
0.9816
–5.10−5
0.9881
0.4619
0.0616
0.9897
Slow stage
9.10−6
0.8987
–0.0026
0.7216
7.10−5
0.9291
–3.10−6
0.8987
0.0426
0.1644
0.7707
ZO : zero-order kinetics; FO : first-order kinetics; HG : Higuchi model; HC : Hixson–Croswell model; KP : Korsmeyer–Peppas model.
